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Article

Hereditary deficiency of protein C or protein S confers increased risk of arterial thromboembolic events at a young age: results from a large family cohort study.

Circulation - 14 Oct 2008

Mahmoodi Bakhtawar K, Brouwer Jan-Leendert P, Veeger Nic J G M, van der Meer Jan

Abstract excerpt

BACKGROUND: Whether hereditary protein S, protein C, or antithrombin deficiency is associated with arterial thromboembolism (ATE) and whether history of venous thromboembolism in these subjects predisposes them to subsequent ATE have yet to be determined. METHODS AND RESULTS: On the basis of pedigree analysis, we enrolled a total of 552 subjects (52% women; mean age, 46+/-17 years), belonging to 84 different...

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PMID: 18824642
DOI: 10.1161/CIRCULATIONAHA.108.780759

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