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Article

Chemometrical identification of mutations in HIV-1 reverse transcriptase conferring resistance or enhanced sensitivity to arylsulfonylbenzonitriles.

Journal of the American Chemical Society - 10 Mar 2004

Rodríguez-Barrios Fátima, Gago Federico

Abstract excerpt

A comparative binding energy (COMBINE) analysis on a series of nonnucleosidic reverse transcriptase inhibitors yields a QSAR model with high predictive ability and correctly identifies the effect of mutations on relevant protein residues.

Read the complete abstract on PubMed

Topics

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Share to Drug Resistance, Viral
Share to HIV-1
Share to HIV Reverse Transcriptase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nitriles

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Source

Identifiers

PMID: 14995186
DOI: 10.1021/ja038893t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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