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Article

Structure-based phenotyping predicts HIV-1 protease inhibitor resistance.

Protein science : a publication of the Protein Society - 1 Aug 2003

Shenderovich Mark D, Kagan Ron M, Heseltine Peter N R, Ramnarayan Kal

Abstract excerpt

Mutations in HIV-1 drug targets lead to resistance and consequent therapeutic failure of antiretroviral drugs. Phenotypic resistance assays are time-consuming and costly, and genotypic rules-based interpretations may fail to predict the effects of multiple mutations. We have developed a computati...

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Identifiers

PMID: 12876320
DOI: 10.1110/ps.0301103
PMCID: PMC2323957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12876320-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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