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Disulfide bonds in merozoite surface protein 1 of the malaria parasite impede efficient antigen processing and affect the <i>in vivo</i> antibody response

25 Feb 2004

Abstract excerpt

The 19 kDa C-terminal fragment of the malaria parasite merozoite surface protein 1 (MSP1(19)) is a leading malaria vaccine candidate. In rodents, high antibody levels to this protein confer protective immunity, and can be generated by immunization with the antigen in adjuvants. In natural human infections, however, MSP1(19)-specific antibody responses can be short-lived and comparatively low, despite repeated...

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PMID: 14991593
DOI: 10.1002/eji.200324514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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