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Article

Expression and antigenicity of Plasmodium falciparum major merozoite surface protein (MSP1(19)) variants secreted from Saccharomyces cerevisiae.

Molecular and biochemical parasitology - 1 Feb 1994

Kaslow D C, Hui G, Kumar S

Abstract excerpt

Four antigenic variants of the 19-kDa carboxy terminal fragment of Plasmodium falciparum merozoite surface protein, MSP1 (MSP1(19)), were expressed in Saccharomyces cerevisiae as a histidine-tagged, secreted polypeptides (rMSP1(19)s). Structural analysis of the rMSP1(19)s indicated that a single amino acid change (E to Q) in the first EGF-like domain of the yeast-secreted rMSP1(19) proteins caused a significant...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibodies, Viral
Antigens, Protozoan
B-Lymphocytes
Base Sequence
Binding, Competitive
Enzyme-Linked Immunosorbent Assay
Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epitopes

Genetic Variation

Merozoite Surface Protein 1

Molecular Sequence Data

Peptide Fragments

Plasmodium falciparum

Protein Conformation

Protein Precursors

Source

Identifiers

PMID: 7516493
DOI: 10.1016/0166-6851(94)90064-7

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7516493-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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