Article
Antigenic and sequence diversity at the C-terminus of the merozoite surface protein-1 from rodent malaria isolates, and the binding of protective monoclonal antibodies.
Molecular and biochemical parasitology - 30 Nov 1999
Benjamin P A, Ling I T, Clottey G, Valero L M, Ogun S A, Fleck S L, Walliker D, Morgan W D, Birdsall B, Feeney J, Holder A A
Abstract excerpt
Merozoite surface protein-1 (MSP-1) is a major candidate in the development of a vaccine against malaria. Immunisation with a recombinant fusion protein containing the two Plasmodium yoelii MSP-1 C-terminal epidermal growth factor-like domains (MSP-1(19)) can protect mice against homologous but not heterologous challenge, and therefore, antigenic differences resulting from sequence diversity in MSP-1(19) may be...
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