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Article

Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants.

Journal of virology - 1 Mar 2004

Saenz Dyana T, Loewen Nils, Peretz Mary, Whitwam Todd, Barraza Román, Howell Kyle G, Holmes Jonathan M, Good Margaret, Poeschla Eric M

Abstract excerpt

The circumstances under which unintegrated lentivirus DNA can persist and be a functional template for transcription and protein expression are not clear. We constructed and validated the first class I (nonpleiotropic) integrase (IN) mutants for a non-human lentivirus (feline immunodeficiency virus [FIV]) and analyzed both these and known class I human immunodeficiency virus type 1 IN mutants. The FIV IN mutants...

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Source

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Identifiers

PMID: 14990709
DOI: 10.1128/jvi.78.6.2906-2920.2004
PMCID: PMC353756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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