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Novel Integrase-Defective Lentiviral Episomal Vectors for Gene Transfer

29 Mar 2004

Abstract excerpt

High levels of circular viral extrachromosomal DNA (E-DNA) are normally produced after infection with integration-competent and -incompetent lentiviruses. Although E-DNA has been shown to be transcriptionally active, it lasts for only a short time in replicating cells. Here, we report an integrase (IN)-defective lentiviral episomal vector in which insertion of the simian virus 40 (SV40) promoter, containing the...

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PMID: 15053861
DOI: 10.1089/104303404322959515

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