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Article

The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons.

The Journal of biological chemistry - 14 May 2004

Fiorani Paola, Reid Robert J D, Schepis Antonino, Jacquiau Hervé R, Guo Hong, Thimmaiah Padma, Benedetti Piero, Bjornsti Mary-Ann

Abstract excerpt

DNA topoisomerase I (Top1p) catalyzes changes in DNA topology via the formation of an enzyme-DNA covalent complex that is reversibly stabilized by the antitumor drug, camptothecin (CPT). During S-phase, collisions with replication forks convert these complexes into cytotoxic DNA lesions that trigger cell cycle arrest and cell death. To investigate cellular responses to CPT-induced DNA damage, a yeast genetic...

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Identifiers

PMID: 14990574
DOI: 10.1074/jbc.M312338200

Genes

SLA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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