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Human Mesenchymal Stem Cells as a Gene Delivery System to Create Cardiac Pacemakers

2 Mar 2004

Abstract excerpt

We tested the ability of human mesenchymal stem cells (hMSCs) to deliver a biological pacemaker to the heart. hMSCs transfected with a cardiac pacemaker gene, mHCN2, by electroporation expressed high levels of Cs+-sensitive current (31.1+/-3.8 pA/pF at -150 mV) activating in the diastolic potential range with reversal potential of -37.5+/-1.0 mV, confirming the expressed current as I(f)-like. The expressed...

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PMID: 14988226
DOI: 10.1161/01.res.0000123827.60210.72

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