Article
Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function.
Circulation. Arrhythmia and electrophysiology - 1 May 2017
Chauveau Samuel, Anyukhovsky Evgeny P, Ben-Ari Meital, Naor Shulamit, Jiang Ya-Ping, Danilo Peter, Rahim Tania, Burke Stephanie, Qiu Xiaoliang, Potapova Irina A, Doronin Sergey V, Brink Peter R, Binah Ofer, Cohen Ira S, Rosen Michael R
Abstract excerpt
BACKGROUND: Although multiple approaches have been used to create biological pacemakers in animal models, induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have not been investigated for this purpose. We now report pacemaker function of iPSC-CMs in a canine model. METHODS AND RESULTS: Embryoid bodies were derived from human keratinocytes, their action potential characteristics determined, and their...
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