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Article

Creation of a Biological Pacemaker by Cell Fusion

29 Mar 2007

Abstract excerpt

As an alternative to electronic pacemakers, we explored the feasibility of converting ventricular myocytes into pacemakers by somatic cell fusion. The idea is to create chemically induced fusion between myocytes and syngeneic fibroblasts engineered to express HCN1 pacemaker channels (HCN1-fibroblasts). HCN1-fibroblasts were fused with freshly isolated guinea pig ventricular myocytes using polyethylene-glycol...

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PMID: 17395872
DOI: 10.1161/01.res.0000265845.04439.78

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