Article
Glycogen synthase kinase-3 beta is involved in the phosphorylation and suppression of androgen receptor activity.
The Journal of biological chemistry - 30 Apr 2004
Salas Thomas R, Kim Jeri, Vakar-Lopez Funda, Sabichi Anita L, Troncoso Patricia, Jenster Guido, Kikuchi Akira, Chen Shao-Yong, Shemshedini Lirim, Suraokar Milind, Logothetis Christopher J, DiGiovanni John, Lippman Scott M, Menter David G
Abstract excerpt
Kinases can phosphorylate and regulate androgen receptor activity during prostate cancer progression. In particular, we showed that glycogen synthase kinase-3 beta phosphorylates the androgen receptor, thereby inhibiting androgen receptor-driven transcription. Conversely, the glycogen synthase kinase-3 beta inhibitor lithium chloride suppressed the glycogen synthase kinase-3 beta-mediated phosphorylation of the...
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