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Article

Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity.

Protein engineering - 1 Dec 2003

Rao Balaji M, Girvin Andrew T, Ciardelli Thomas, Lauffenburger Douglas A, Wittrup K Dane

Abstract excerpt

Stimulation of T-cells by IL-2 has been exploited for treatment of metastatic renal carcinoma and melanoma. However, a narrow therapeutic window delimited by negligible stimulation of T-cells at low picomolar concentrations and undesirable stimulation of NK cells at nanomolar concentrations hampers IL-2-based therapies. We hypothesized that increasing the affinity of IL-2 for IL-2Ralpha may create a class of IL-2...

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Source

Identifiers

PMID: 14983090
DOI: 10.1093/protein/gzg111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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