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Article

Proline versus charge concept for protein stabilization against proteolytic attack.

Protein engineering - 1 Dec 2003

Markert Yvonne, Köditz Jens, Ulbrich-Hofmann Renate, Arnold Ulrich

Abstract excerpt

The virtue of the so-called 'proline concept' and the 'charge concept' for stabilizing protease-susceptible regions of a protein structure was compared on bovine pancreatic ribonuclease A. Alanine 20 and serine 21, both of which are located in a loop that is susceptible to the unspecific proteases subtilisin Carlsberg, subtilisin BPN', proteinase K and elastase, were replaced with proline or lysine by...

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Identifiers

PMID: 14983085
DOI: 10.1093/protein/gzg136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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