Article
A critical view on conservative mutations.
Protein engineering - 1 Jun 2001
Jonson P H, Petersen S B
Abstract excerpt
By analysing the surface composition of a set of protein 3D structures, complemented with predicted surface compositional information for homologous proteins, we have found significant evidence for a layer composition of protein structures. In the innermost and outermost parts of proteins there is a net negative charge, while the middle has a net positive charge. In addition, our findings indicate that the...
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