Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Artemis and p53 cooperate to suppress oncogenic <i>N-myc</i> amplification in progenitor B cells

12 Feb 2004

Abstract excerpt

The nonhomologous DNA end-joining (NHEJ) pathway contains six known components, including Artemis, a nuclease mutated in a subset of human severe combined immunodeficient patients. Mice doubly deficient for the five previously analyzed NHEJ factors and p53 inevitably develop progenitor B lymphomas harboring der(12)t(12;15) translocations and immunoglobin heavy chain (IgH)/c-myc coamplification mediated by a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14983023
DOI: 10.1073/pnas.0308757101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Artemis and p53 cooperate to suppress oncogenic <i>N-myc</i> amplification in progenitor B cellsPMID 14983023Read ↗

A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.Semantic proximity Read ↗

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.Semantic proximity Read ↗

Artemis, a novel guardian of the genome.Semantic proximity Read ↗

The V(D)J recombination/DNA repair factor artemis belongs to the metallo-beta-lactamase family and constitutes a critical developmental checkpoint of the lymphoid system.Semantic proximity Read ↗

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.Semantic proximity Read ↗

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombinationSemantic proximity Read ↗

A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation.Semantic proximity Read ↗

Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability.Semantic proximity Read ↗

Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families.Semantic proximity Read ↗

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis.Semantic proximity Read ↗

Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency.Semantic proximity Read ↗

Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.