Article
Fos modulates myeloid cell survival and differentiation and partially abrogates the c-Myc block in terminal myeloid differentiation.
Blood - 1 Jun 2004
Shafarenko Marianna, Amanullah Arshad, Gregory Bernard, Liebermann Dan A, Hoffman Barbara
Abstract excerpt
Previously, we have shown that Fos/Jun transcription factor complexes function as positive modulators of myeloid differentiation. Fos, which is stably induced during normal myeloid differentiation, is not induced upon differentiation of M1 myeloblastic leukemia cells. Establishing M1 cells that express a beta-estradiol-conditional FosER chimera, we show that in the absence of the differentiation inducer...
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