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Improving rAAV production and purification: towards the definition of a scaleable process

1 Feb 2004

Abstract excerpt

Numerous in vivo studies have demonstrated that recombinant AAV-2 vectors (rAAV-2) can efficiently transduce many tissues and lead to stable gene expression 12. These encouraging results have led to a rapid development of clinical trials involving the use of rAAV-2 vectors 3. However, the obtainment of large-scale rAAV-2 vector stocks for clinical assay is still hampered by the conventional production and...

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PMID: 14978765
DOI: 10.1002/jgm.505

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