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Article

Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.

Journal of medicinal chemistry - 26 Feb 2004

Chan Joseph H, Freeman George A, Tidwell Jeffrey H, Romines Karen R, Schaller Lee T, Cowan Jill R, Gonzales Steve S, Lowell Gina S, Andrews C W, Reynolds David J, St Clair Marty, Hazen Richard J, Ferris Rob G, Creech Katrina L, Roberts Grace B, Short Steven A, Weaver Kurt, Koszalka George W, Boone Lawrence R

Abstract excerpt

GW4511, GW4751, and GW3011 showed IC50 values < or =2 nM against wild type HIV-1 and <10 nM against 16 mutants. They were particularly potent against NNRTI-resistant viruses containing Y181C-, K103N-, and K103N-based double mutations, which account for a significant proportion of the clinical failure of the three currently marketed NNRTIs. The antiviral data together with the favorable pharmacokinetic data of...

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Identifiers

PMID: 14971897
DOI: 10.1021/jm030255y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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