Article
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
Journal of medicinal chemistry - 26 Jan 2006
Romines Karen R, Freeman George A, Schaller Lee T, Cowan Jill R, Gonzales Steve S, Tidwell Jeffrey H, Andrews Clarence W, Stammers David K, Hazen Richard J, Ferris Robert G, Short Steven A, Chan Joseph H, Boone Lawrence R
Abstract excerpt
Despite the progress of the past two decades, there is still considerable need for safe, efficacious drugs that target human immunodeficiency virus (HIV). This is particularly true for the growing number of patients infected with virus resistant to currently approved HIV drugs. Our high throughput screening effort identified a benzophenone template as a potential nonnucleoside reverse transcriptase inhibitor...
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