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Article

Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Bioorganic & medicinal chemistry - 1 Aug 2011

Ma Xiao-Dong, Zhang Xuan, Dai Hui-Fang, Yang Shi-Qiong, Yang Liu-Meng, Gu Shuang-Xi, Zheng Yong-Tang, He Qiu-Qin, Chen Fen-Er

Abstract excerpt

A novel series of benzophenone derivatives with B-ring substituted by naphthyl ring has been synthesized and evaluated as non-nucleoside HIV-1 reverse transcriptase inhibitors. Most of these compounds showed good to moderate activity against wild-type HIV-1 and mutated viruses. In particular, the analogue 10i demonstrated the most potent activity against wild-type HIV-1 with an EC₅₀ value of 4.8 nM, and with a...

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Identifiers

PMID: 21719299
DOI: 10.1016/j.bmc.2011.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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