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Article

Demethylation of MAGE promoters during gastric cancer progression

1 Feb 2004

Abstract excerpt

Melanoma antigen (MAGE)-encoding genes are expressed in various tumour types via demethylation of their promoter CpG islands, which are silent in all non-neoplastic tissues except for the testis and placenta. The clinicopathological significance of demethylation of MAGE genes in gastric carcinoma is not known. We investigated the promoter methylation status of MAGE-A1 and -A3 in 10 gastric cancer cell lines and...

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PMID: 14970862
DOI: 10.1038/sj.bjc.6601600

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