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Article

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

17 Feb 2004

Abstract excerpt

Resistance to chemotherapy is a major cause of mortality in advanced cancer patients. In this study, digital karyotyping was used to search for genomic alterations in liver metastases that were clinically resistant to 5-fluorouracil (5-FU). In two of four patients, we identified amplification of an approximately 100-kb region on 18p11.32 that was of particular interest because it contained the gene encoding...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
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PMID: 14970324
DOI: 10.1073/pnas.0308716101

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