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Article

Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil

1 May 1995

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 7763285
DOI: 10.1016/0006-2952(95)00067-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracilPMID 7763285Read ↗

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patientsSemantic proximity Read ↗

MicroRNA-197 influences 5-fluorouracil resistance via thymidylate synthase in colorectal cancerSemantic proximity Read ↗

Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.Semantic proximity Read ↗

Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancerSemantic proximity Read ↗

Thymidylate synthase polymorphism in Mexican patients with colon cancer treated with 5-fluorouracil.Semantic proximity Read ↗

Thymidylate synthase genotyping is more predictive for therapy response than immunohistochemistry in patients with colon cancer.Semantic proximity Read ↗

Acquired resistance to 5-fluorouracilviaHSP90/Src-mediated increase in thymidylate synthase expression in colon cancerSemantic proximity Read ↗

Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not FluorouracilSemantic proximity Read ↗

Sequence-dependent growth inhibition and DNA damage formation by the irinotecan–5-fluorouracil combination in human colon carcinoma cell linesSemantic proximity Read ↗

Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.Semantic proximity Read ↗

Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivoSemantic proximity Read ↗

Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents.Semantic proximity Read ↗

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