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Article

MicroRNA-330 inhibited cell proliferation and enhanced chemosensitivity to 5-fluorouracil in colorectal cancer by directly targeting thymidylate synthase

23 Mar 2017

Abstract excerpt

Colorectal cancer (CRC) is the third most common cancer in males and the second most common in females, worldwide. Currently, 5-fluorouracil (5-FU)-mediated chemotherapy is the adjuvant treatment for patients with CRC following surgical resection. However, a number of patients with CRC develop 5‑FU resistance, which is a major challenge for the effective treatment of cancer. Therefore, it is important to...

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PMID: 28521444
DOI: 10.3892/ol.2017.5895

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