Article
P2X1 Selective Antagonists Block HIV-1 Infection through Inhibition of Envelope Conformation-Dependent Fusion.
Journal of virology - 28 Feb 2020
Soare Alexandra Y, Malik Hagerah S, Durham Natasha D, Freeman Tracey L, Alvarez Raymond, Patel Foramben, Satija Namita, Upadhyay Chitra, Hioe Catarina E, Chen Benjamin K, Swartz Talia H
Abstract excerpt
Purinergic receptors are well-established modulators of inflammatory processes, primarily through detection of extracellular nucleotides that are released by dying or infected cells. Emerging literature has demonstrated that inhibition of these inflammatory receptors can block HIV-1 productive infection and HIV-1-associated inflammation. The specificity of receptor type and mechanism of interaction has not yet...
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