Article
Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal.
Retrovirology - 17 Jul 2012
Van Rompay Koen K A, Trott Kristin A, Jayashankar Kartika, Geng Yongzhi, LaBranche Celia C, Johnson Jeffrey A, Landucci Gary, Lipscomb Jonathan, Tarara Ross P, Canfield Don R, Heneine Walid, Forthal Donald N, Montefiori David, Abel Kristina
Abstract excerpt
BACKGROUND: We reported previously that while prolonged tenofovir monotherapy of macaques infected with virulent simian immunodeficiency virus (SIV) resulted invariably in the emergence of viral mutants with reduced in vitro drug susceptibility and a K65R mutation in reverse transcriptase, some animals controlled virus replication for years. Transient CD8+ cell depletion or short-term tenofovir interruption...
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