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Article

Population dynamics of immune responses to persistent viruses.

Science (New York, N.Y.) - 5 Apr 1996

Nowak M A, Bangham C R

Abstract excerpt

Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on...

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PMID: 8600540
DOI: 10.1126/science.272.5258.74

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