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1,25-dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter.

Atherosclerosis - 1 May 2009

Cardus Anna, Panizo Sara, Encinas Mario, Dolcet Xavier, Gallego Carme, Aldea Martí, Fernandez Elvira, Valdivielso Jose M

Abstract excerpt

In previous studies we have demonstrated that the active form of vitamin D (1,25(OH)(2)D(3)) increases vascular endothelial growth factor (VEGF) expression and release in vascular smooth muscle cells (VSMC) in vitro. However, the mechanism by which 1,25(OH)(2)D(3) increases VEGF production is currently unknown. In this work, we demonstrated binding of vitamin D receptor to two response elements in the VEGF...

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PMID: 18834982
DOI: 10.1016/j.atherosclerosis.2008.08.020

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