Article
Analysis of protease inhibitor combinations in vitro: activity of lopinavir, amprenavir and tipranavir against HIV type 1 wild-type and drug-resistant isolates.
The Journal of antimicrobial chemotherapy - 1 Mar 2004
Bulgheroni Elisabetta, Citterio Paola, Croce Francesco, Lo Cicero Mirko, Viganò Ottavia, Soster Francesca, Chou Ting-Chao, Galli Massimo, Rusconi Stefano
Abstract excerpt
BACKGROUND: Despite the increasing number of antiretroviral compounds, the number of useful drug regimens is limited owing to the high frequency of cross-resistance. PATIENTS AND METHODS: We studied in vitro two-drug combinations using three protease inhibitors (PIs), tipranavir, amprenavir and lopinavir, on isolates (003 and 004) derived from patients with resistance to multiple PIs compared with the...
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