Article
Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis.
Neurology - 10 Feb 2004
Torisu H, Kusuhara K, Kira R, Bassuny W M, Sakai Y, Sanefuji M, Takemoto M, Hara T
Abstract excerpt
BACKGROUND: The antivirally active MxA protein is induced by interferon (IFN) alpha/beta and inhibits the replication of single-stranded RNA viruses including measles virus (MV). The authors investigated whether the MxA gene contributed to the development of subacute sclerosing panencephalitis (SSPE) in Japanese individuals. METHODS: Single-nucleotide polymorphisms (SNP) in the promoter region of the MxA gene...
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