Article
PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis.
Human genetics - 1 Apr 2010
Ishizaki Yoshito, Yukaya Naoko, Kusuhara Koichi, Kira Ryutaro, Torisu Hiroyuki, Ihara Kenji, Sakai Yasunari, Sanefuji Masafumi, Pipo-Deveza Judy R, Silao Catherine Lynn T, Sanchez Benilda C, Lukban Marissa B, Salonga Aida M, Hara Toshiro
Abstract excerpt
Although the exact pathogenesis of subacute sclerosing panencephalitis (SSPE) remains to be determined, our previous data suggested a genetic contribution to the host susceptibility to SSPE. During chronic viral infection, virus-specific cytotoxic T lymphocytes display poor effector functions. Since co-inhibitory molecules are involved in the suppression of T lymphocytes, we investigated whether single nucleotide...
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