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Article

Amino acid similarity matrices based on force fields.

Bioinformatics (Oxford, England) - 1 Aug 2001

Dosztányi Z, Torda A E

Abstract excerpt

MOTIVATION: We propose a general method for deriving amino acid substitution matrices from low resolution force fields. Unlike current popular methods, the approach does not rely on evolutionary arguments or alignment of sequences or structures. Instead, residues are computationally mutated and their contribution to the total energy/score is collected. The average of these values over each position within a set...

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PMID: 11524370
DOI: 10.1093/bioinformatics/17.8.686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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