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Article

Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences.

Molecular microbiology - 1 Nov 1992

Romano N, Macino G

Abstract excerpt

Up to 36% of Neurospora crassa transformants showing an albino phenotype were recovered by transforming a wild-type strain with different portions of the carotenogenic albino-3 (al-3) and albino-1 (al-1) genes. The presence of the exogenous sequences (which were randomly integrated in ectopic locations) provoked a severe impairment in the expression of the endogenous al-1 or al-3 genes. This phenomenon, which we...

Topics

Alkyl and Aryl Transferases
Carotenoids
Enzyme Induction
Farnesyltranstransferase
Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal
Neurospora crassa
Oxidoreductases
Phenotype
Pigmentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Transferases

Transformation, Genetic

Source

Identifiers

PMID: 1484489
DOI: 10.1111/j.1365-2958.1992.tb02202.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1484489-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences.PMID 1484489Read ↗

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