Article
Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences.
Molecular microbiology - 1 Nov 1992
Romano N, Macino G
Abstract excerpt
Up to 36% of Neurospora crassa transformants showing an albino phenotype were recovered by transforming a wild-type strain with different portions of the carotenogenic albino-3 (al-3) and albino-1 (al-1) genes. The presence of the exogenous sequences (which were randomly integrated in ectopic locations) provoked a severe impairment in the expression of the endogenous al-1 or al-3 genes. This phenomenon, which we...
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