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Article

Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997

Cogoni C, Macino G

Abstract excerpt

We report the isolation of 15 Neurospora crassa mutants defective in "quelling" or transgene-induced gene silencing. These quelling-defective mutants (qde) belonging to three complementation groups have provided insights into the mechanism of posttranscriptional gene silencing in N. crassa. The recessive nature of the qde mutations indicates that the encoded gene products act in trans. We show that when qde genes...

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Identifiers

PMID: 9294193
DOI: 10.1073/pnas.94.19.10233
PMCID: PMC23345

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa.PMID 9294193Read ↗

Post-transcriptional gene silencing mutants.Semantic proximity Read ↗

The RNA-dependent RNA polymerase, QDE-1, is a rate-limiting factor in post-transcriptional gene silencing in Neurospora crassa.Semantic proximity Read ↗

Redundancy of the two dicer genes in transgene-induced posttranscriptional gene silencing in Neurospora crassa.Semantic proximity Read ↗

Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences.Semantic proximity Read ↗

Quelling in Neurospora crassa.Semantic proximity Read ↗

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals.Semantic proximity Read ↗

The QDE-3 homologue RecQ-2 co-operates with QDE-3 in DNA repair in Neurospora crassa.Semantic proximity Read ↗

Suppression of gene expression by homologous transgenes.Semantic proximity Read ↗

The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa.Semantic proximity Read ↗

Post-transcriptional gene silencing triggered by sense transgenes involves uncapped antisense RNA and differs from silencing intentionally triggered by antisense transgenes.Semantic proximity Read ↗

Gene silencing: RNA makes RNA makes no protein.Semantic proximity Read ↗

Down-regulation of gene expression by RNA-induced gene silencing.Semantic proximity Read ↗

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