Article
Molecular evidence of anaplastic transformation in coexisting well-differentiated and anaplastic carcinomas of the thyroid.
The American journal of surgical pathology - 1 Dec 2003
Hunt Jennifer L, Tometsko Michael, LiVolsi Virginia A, Swalsky Patricia, Finkelstein Sydney D, Barnes E Leon
Abstract excerpt
Anaplastic thyroid cancer is a rare but nearly universally fatal tumor. Epidemiologic data suggest that many anaplastic thyroid carcinomas arise from transformation of preexisting or coexisting well-differentiated thyroid carcinomas. At the molecular level, the mutations responsible for the anaplastic transformation are incompletely understood, although the mutational events are thought to involve tumor...
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