Lack of allelic preference in amplification and loss of the c-myc oncogene in methylcholanthrene-induced mouse sarcomas.

doi:10.1111/j.1349-7006.1992.tb02744.x

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Article

Lack of allelic preference in amplification and loss of the c-myc oncogene in methylcholanthrene-induced mouse sarcomas.

Japanese journal of cancer research : Gann - 1 Nov 1992

Niwa O, Kominami R

Abstract excerpt

Sarcomas were induced in F1 mice between C57BL/6N and C3H/He strains by subcutaneous injection of methylcholanthrene. The c-myc oncogene was found to be amplified in 16 cases among 43 sarcomas of C57BL/6N x C3H/He mice and 1 case among 5 sarcomas of the reciprocal cross. The origin of the amplifi...

Topics

Alleles
Animals
DNA, Neoplasm
DNA, Single-Stranded
Female
Gene Amplification
Genes, myc
Male
Methylcholanthrene
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Polymerase Chain Reaction
Polymorphism, Genetic
Sarcoma, Experimental

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