Article
Elevated frequency of a specific allele of the L-myc gene in male patients with bone and soft-tissue sarcomas.
International journal of cancer - 15 Jan 1990
Kato M, Toguchida J, Honda K, Sasaki M S, Ikenaga M, Sugimoto M, Yamaguchi T, Kotoura Y, Yamamuro T, Ishizaki K
Abstract excerpt
Restriction fragment length polymorphisms (RFLPs) of 2 oncogenes, c-Ha-ras and L-myc, have been analyzed in 101 patients with bone and soft-tissue sarcoma and in 98 normal individuals. The c-Ha-ras gene was highly polymorphic both in sarcoma patients and in normal individuals. In contrast to our previous observation in breast cancer patients (Honda et al., 1988), no significant difference in allele frequencies...
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