Article
Elevated frequency of a specific allele of the L-myc gene in male patients with bone and soft-tissue sarcomas.
International journal of cancer - 15 Jan 1990
Kato M, Toguchida J, Honda K, Sasaki M S, Ikenaga M, Sugimoto M, Yamaguchi T, Kotoura Y, Yamamuro T, Ishizaki K
Abstract excerpt
Restriction fragment length polymorphisms (RFLPs) of 2 oncogenes, c-Ha-ras and L-myc, have been analyzed in 101 patients with bone and soft-tissue sarcoma and in 98 normal individuals. The c-Ha-ras gene was highly polymorphic both in sarcoma patients and in normal individuals. In contrast to our...
Topics
- Alleles
- Blotting, Southern
- Bone Neoplasms
- DNA
- DNA Probes
- Gene Frequency
- Genes, ras
- Genetic Predisposition to Disease
- Humans
- Male
- Oncogenes
- Polymorphism, Restriction Fragment Length
- Sarcoma
- Sex Characteristics
- Soft Tissue Neoplasms