Article
Selection of resistant mutants of Mycobacterium avium in beige mice by clarithromycin monotherapy.
Antimicrobial agents and chemotherapy - 1 Dec 1992
Ji B, Lounis N, Truffot-Pernot C, Grosset J
Abstract excerpt
Beige mice were inoculated intravenously with 10(7.90) CFU of Mycobacterium avium 101. Among the untreated control mice, when the mean CFU per spleen increased to a level greater than 10(8), small numbers of organisms resistant to clarithromycin (CLARI) were isolated from some of the spleens; the frequency of CLARI-resistant mutants was estimated to be between 10(-8) and 10(-9). In mice treated with 200 mg of...
Topics
- Animals
- Clarithromycin
- Drug Resistance, Microbial
- Mice
- Mice, Inbred Strains
- Mutation
- Mycobacterium avium
- Spleen