Development of macrolide resistance in Bordetella bronchiseptica is associated with the loss of virulence.

doi:10.1093/jac/dky264

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Article

Development of macrolide resistance in Bordetella bronchiseptica is associated with the loss of virulence.

The Journal of antimicrobial chemotherapy - 1 Oct 2018

Dewan Kalyan K, Skarlupka Amanda L, Rivera Israel, Cuff Laura E, Gestal Monica C, Taylor-Mulneix Dawn L, Wagner Shannon, Ryman Valerie E, Rodriguez Coralis, Hamidou Soumana Illiassou, Levin Bruce R, Harvill Eric T

Abstract excerpt

Background: Why resistance to specific antibiotics emerges and spreads rapidly in some bacteria confronting these drugs but not others remains a mystery. Resistance to erythromycin in the respiratory pathogens Staphylococcus aureus and Streptococcus pneumoniae emerged rapidly and increased problematically. However, resistance is uncommon amongst the classic Bordetella species despite infections being treated with...

Topics

Animals
Anti-Bacterial Agents
Bacterial Adhesion
Bacterial Toxins
Bordetella Infections
Bordetella bronchiseptica
Cell Survival
Cytokines
Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance, Bacterial

Erythromycin

Mice

Mutation

Selection, Genetic

Serial Passage

Virulence

Source

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Identifiers

PMID: 30107601
DOI: 10.1093/jac/dky264
PMCID: PMC6148206

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