Article
Selection of clarithromycin-resistant Mycobacterium avium complex during combined therapy using the beige mouse model.
Antimicrobial agents and chemotherapy - 1 Mar 1995
Lounis N, Ji B, Truffot-Pernot C, Grosset J
Abstract excerpt
Sixteen weeks of treatment with clarithromycin (CLARI) alone displayed significant bactericidal activity against Mycobacterium avium complex infection in beige mice. Only two combined regimens, CLARI combined with an initial 4 or 8 weeks of amikacin (AMIKA), displayed activity greater than that d...
Topics
- Amikacin
- Animals
- Clarithromycin
- Drug Resistance, Microbial
- Ethambutol
- Female
- Humans
- Lung
- Mice
- Mice, Inbred C57BL
- Microbial Sensitivity Tests
- Mutation
- Mycobacterium avium Complex
- Mycobacterium avium-intracellulare Infection
- Rifabutin
- Spleen