Article
Detection of the most common mutations causing beta-thalassemia in Mediterraneans using a multiplex amplification refractory mutation system (MARMS).
PCR methods and applications - 1 Nov 1992
Fortina P, Dotti G, Conant R, Monokian G, Parrella T, Hitchcock W, Rappaport E, Schwartz E, Surrey S
Abstract excerpt
A rapid, simple, cost-effective, non-radioactive method for detection of the most common mutations causing beta-thalassemia in Mediterranean people has been developed by combining multiplexing with the amplification refractory system. This approach, the multiplex amplification refractory mutation...
Topics
- Alleles
- Base Sequence
- DNA Mutational Analysis
- Gene Frequency
- Genotype
- Globins
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- beta-Thalassemia