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Article

Polymerase chain reaction (PCR) mutagenesis enabling rapid non-radioactive detection of common beta-thalassaemia mutations in Mediterraneans.

British journal of haematology - 1 May 1991

Lindeman R, Hu S P, Volpato F, Trent R J

Abstract excerpt

The IVS-1-110 (G----A) and IVS-1-1 (G----A) mutations occur in approximately 33% and 9% respectively of beta-thalassaemia alleles in Mediterraneans (Kazazian & Boehm, 1988). They are generally detected in polymerase chain reaction (PCR)-amplified material by allele-specific oligonucleotide (ASO) hybridization patterns. In this study, artificial base substitutions in amplified material have been created to...

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Identifiers

PMID: 1675115
DOI: 10.1111/j.1365-2141.1991.tb04389.x

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