Detection of eight beta-thalassemia mutations using a DNA enzyme immunoassay.

doi:10.1007/BF02592357

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Article

Detection of eight beta-thalassemia mutations using a DNA enzyme immunoassay.

International journal of clinical & laboratory research - 1 Jan 1996

Colosimo A, Novelli G, Cavicchini A, Dallapiccola B

Abstract excerpt

We describe the use of a polymerase chain reaction-based method followed by a DNA enzyme immunoassay for the simultaneous detection of the eight most common beta-thalassemia mutations in the Mediterranean population. The method is specific, sensitive, and easily applicable in routine clinical lab...

Topics

Alleles
Case-Control Studies
DNA
Globins
Humans
Immunoenzyme Techniques
Italy
Mass Screening
Microchemistry
Mutation
Polymerase Chain Reaction
Sensitivity and Specificity
Titrimetry
beta-Thalassemia

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