Article
Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families.
Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2004
Friedrichsen Danielle M, Stanford Janet L, Isaacs Sarah D, Janer Marta, Chang Bao-Li, Deutsch Kerry, Gillanders Elizabeth, Kolb Suzanne, Wiley Katherine E, Badzioch Michael D, Zheng S Lilly, Walsh Patrick C, Jarvik Gail P, Hood Leroy, Trent Jeffrey M, Isaacs William B, Ostrander Elaine A, Xu Jianfeng
Abstract excerpt
Results from over a dozen prostate cancer susceptibility genome-wide scans, encompassing some 1,500 hereditary prostate cancer families, indicate that prostate cancer is an extremely heterogeneous disease with multiple loci contributing to overall susceptibility. In an attempt to reduce locus heterogeneity, we performed a genomewide linkage scan for prostate cancer susceptibility genes with 36 Jewish families,...
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