Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry.

doi:10.1007/s00439-012-1139-5

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Article

Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry.

Human genetics - 1 Jul 2012

Wang Zhaoming, Parikh Hemang, Jia Jinping, Myers Timothy, Yeager Meredith, Jacobs Kevin B, Hutchinson Amy, Burdett Laurie, Ghosh Arpita, Thun Michael J, Gapstur Susan M, Ryan Diver W, Virtamo Jarmo, Albanes Demetrius, Cancel-Tassin Geraldine, Valeri Antoine, Cussenot Olivier, Offit Kenneth, Giovannucci Ed, Ma Jing, Stampfer Meir J, Michael Gaziano J, Hunter David J, Dutra-Clarke Ana, Kirchhoff Tomas, Alavanja Michael, Freeman Laura B, Koutros Stella, Hoover Robert, Berndt Sonja I, Hayes Richard B, Agalliu Ilir, Burk Robert D, Wacholder Sholom, Thomas Gilles, Amundadottir Laufey

Abstract excerpt

Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ancestry, we genotyped 34 binary Y chromosome markers in 3,995 prostate cancer cases and 3,815 control subjects drawn from four studies. In this set, we identified nominally significant...

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Identifiers

PMID: 22271044
DOI: 10.1007/s00439-012-1139-5
PMCID: PMC3374121

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