Article
Linkage and association studies of prostate cancer susceptibility: evidence for linkage at 8p22-23.
American journal of human genetics - 1 Aug 2001
Xu J, Zheng S L, Hawkins G A, Faith D A, Kelly B, Isaacs S D, Wiley K E, Chang B, Ewing C M, Bujnovszky P, Carpten J D, Bleecker E R, Walsh P C, Trent J M, Meyers D A, Isaacs W B
Abstract excerpt
Multiple lines of evidence have implicated the short arm of chromosome 8 as harboring genes important in prostate carcinogenesis. Although most of this evidence comes from the identification of frequent somatic alterations of 8p loci in prostate cancer cells (e.g., loss of heterozygosity), studies have also suggested a role for 8p genes in mediation of inherited susceptibility to prostate cancer. To further...
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