Human B cells express a CD45 isoform that is similar to murine B220 and is downregulated with acquisition of the memory B‐cell marker CD27

Abstract excerpt

BACKGROUND: Differences between human and murine B cells exist at all stages of B-cell development, including the stage of memory B-cell formation. B cells in mice are identified with the pan-B-cell-specific CD45 isoform, B220. In initial studies in humans, it appeared that B220 expression did not include all B cells. This study was performed to expand on those preliminary findings. METHODS: Multiparameter flow...

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