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Programmed cell death 6, a novel p53‐responsive gene, targets to the nucleus in the apoptotic response to <scp>DNA</scp> damage

20 Jun 2012

Abstract excerpt

The cellular response to genotoxic stress is multifaceted in nature. Following DNA damage, the tumor suppressor gene p53 activates and plays critical roles in cell cycle arrest, activation of DNA repair and in the event of irreparable damage, induction of apoptosis. The breakdown of apoptosis causes the accumulation of mutant cells. The elucidation of the mechanism for the p53-dependent apoptosis will be crucial...

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PMID: 22712728
DOI: 10.1111/j.1349-7006.2012.02362.x

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